cheers

I applied it rectally and lightly rubbed in into both my forearms. I felt some form of a soothing effect but I am concerned about a skin thinning side effect side effect the pharmacist told me of. But honestly, I can feel some form of relief but I cannot say stress reduction because I am currently not stressed about anything. The Cortef cream is a wonder. Will use when stressed. Cheers.

You can quote this in your thread as a second review of ya want.

Really interesting post. Didn't realize Soviet infrastructure had been so good.

great post!

Hahaha, I've yet to decide on that myself...it's definitely the most ostentatious thing I own. But for some reason, when I saw it, I thought: "I must acquire this immediately."

Interesting post!

I have been known to dance in my lab coat, but only when working late on the weekends. Don't think I'd try that at a bar

Sometimes it just has to be said...

Thank you

hahaha, that was entertaining :-)

A-freaking-men

Because the body would still down regulate its own production to compensate... the rate limiter is built in. The engine can only go so fast.

You can do exercise and eat food that engages human growth hormone production, but you won't look like Arnold because your body will still limit HGH to safe levels. Direct injection will bypass this limit, at the risk of your long term health...pro bodybuilders tend to develop lots of health problems by their 40s.

I agree with your insightful observations.

Its like the difference between sucking on a coca leaf and snorting cocaine. One is more potent than the other. The roundabout way caffeine works is different than swallowing a pill full of cortisol.

Looks like Autumnleaf covered the bases well.

Everything the body produces is controlled by regulating mechanisms which enable homeostasis. The antidiurectichormone (ADH) pathway is a textbook example, one which controls body water levels to prevent dehydration and water poisoning.

If you inject ADH, as they used to do for cardiac arrest, it forces the body to retain water. And screws up about ten other systems ADH controls, including brain function. The body cannot reduce the amount of ADH, as it was directly injected, even if it causes serious problems elsewhere.

As a result, any sort of hormone therapy is akin to fixing the body with a sledgehammer. Cortisone, for example, both reduces inflammation (your desired effect) and triggers a partial stress response. So while you would be relieving your IBS symptoms, you take on the risk of forcing your body into a high-stress state every day. AKA risk developing hyperglycemia, diabetes, osteoporosis, anxiety, or amenorrhoea.

The topical ones are high dose to the skin. The kind secreted by your body are dosed by your body according to feedback mechanism, so the dose is more tailored to you. Also, your body takes steroids and metabolizes it into other steroids which can go male or female depending on the enzymatic pathways that win out in the skin or gut whether you take a pill or use a cream. The body is a huge biomechanical factory when it comes to drugs.

LOL. Well it's not good enough for anyone to want to buy it apparently. I've been marketing the sucker for days on multiple websites and no one's biting.

Corticosteroids supress the immune response by simulating adrenal hormones but that comes with side effects if used over the long term. There's a lot of info out there about it. It's less so with topical application, but those can still have adverse effects if used longer than recommended.

Well, I haven't really had any symptoms or flare ups since then, so I'm not really sure. But I have been using that steroid cream for eczema and it only works minimally when it's bad, so I think maybe my body's inflammation is just auto-immune disease related, and the steroids are not that effective. I do try to use steroids sparingly, though, b/c they bring a lot of bad side effects, like thinning bones, adrenal problems, etc.